Biomarkers in Neuroimaging


Track 23 : Biomarkers in Neuroimaging



Neuroimaging has helped to elucidate that substance-use disorders are related to changes in brain structure, function, and neurochemistryNeuroimaging studies have improved our understanding of the neural correlates of addiction and the way these relate to addictive behaviour. Never the less, the potential impact of neuroimaging on treatment and development for addictions has yet to be fully realized. Despite steady advances, cure for the diseases are often not fully effective, and addiction continues to be a serious public health problem. Neuroimaging has contributed to our appreciation of the complexity of addiction, highlighting the necessity for measurable indices, or biomarkers, of addiction to enhance treatment outcomes. A “biomarker” generally refers to a measurable indicator of normal or abnormal biological processes or response to treatment. In substance-abuse research, biomarkers are needed to clarify how or why a treatment has an impact, on whom and under what circumstances.



 



Recent advances in neuroimaging are affording greater opportunities to spot brain biomarkers which may be wont to improve outcomes of treatment for substance-use disorders. Neuroimaging can be a very critical tool in biomarker development because it relates neural circuits to both molecular mechanisms and behaviour or clinical variations. especially , neuroimaging studies are central to an emerging attempt to spot cross-diagnostic processes in substance-use and related disorders supported both behaviour and neural circuits . during this work, alterations in brain activation patterns related to dimensions of functioning in individuals with addictions could also be considered to represent abnormal processing associated with addictive behaviour.  As disorder heterogeneity pose significant challenges for delivering effective treatment, considering addictions in terms of dimensions of functioning may help to elucidate factors relevant to treatment response and cause more specific, simpler treatments. This paper reviews neuroimaging research seeking to spot potential biomarkers of treatment response from several dimensions of functioning relevant to addictionimpulsivity, and cognitive control.



 


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